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Fibrinogen Gallery

    NOTE: This description is hopelessly out of date. New posting will appear soon.

But for the time being, let me just say that our long time laboratory-based research had been aimed at resolving the protein structure of vertebrate fibrinogen. In the end, this goal was achieved by x-ray crystallography, an approach we undertook, somewhat belatedly, early in the 1990's. In the end we succeeded better than we had ever hoped, managing to obtain crystal structures of both chicken and human fibrinogens.

(Seen below: Space-filling model of D-dimer showing abutting ends at the D:D interface. The isopeptide cross-link between g-chains was not visible in electron density maps and is denoted by the broken line)

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Last Modified Wed. Apr. 12, 2017