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•  Doolittle RF. Jon Singer: Retrospective. Proc. Natl. Acad. Sci., USA 114:3550-3551 (2017)

•  Doolittle RF. The conversion of fibrinogen to fibrin: A brief history of some key events. Matrix Biology (epub) (2016)

•  Doolittle RF.
Some important milestones in the field of blood clotting. J. Innate Immunity 8:23-29 (2016)

•  Doolittle RF.
Bioinformatic characterization of genes and proteins in lampreys.
J. Molecular Evolution 81:121-130 (2015)

•  Doolittle RF.
Clotting of mammalian fibrinogens by papain: a re-examination.
Biochemistry 53:6687-94 (2014)

•  Duttke, SH, Doolittle RF, Wang, Y-L and Kadonaga, J.
TRF2 and the evolution of the bilateria.
Genes and Development 28:2163-2174 (2014)

•  Doolittle RF, K. Mcnamara and K. Lin.
Correlating structure and function during the evolution of fibrinogen-related domains.
Protein Science 18:1808-1823 (2012)

•  Doolittle RF.
Going to the synchrotron.
Unpublished (2000)

•  Doolittle RF.
Harvey Itano-obituary.
National Academy Biographical Memoirs (2012)

•  Watson JW and Doolittle RF.
Peptide-derivatized albumins that inhibit fibrin polymerization.
Biochemistry 50:9923-9927 (2011)

•  Doolittle RF.
The Protochordate Ciona intestinales Has a Protein Like Full-Length Vertebrate Fibrinogen.
J. Innate Immunity 4:219-222 (2012)

•  Doolittle RF.
Coagulation in vertebrate with a focus on evolution and inflammation.
J. Innate Immunity 3:9-16 (2011)

•  Doolittle RF.
The Roots of Bioinformatics in Protein Evolution.
PLoS Computational Biology 6(7)e1000875 (2010)

•  Doolittle RF.
Stepwide Evolution of Vertebrate Blood Clotting.
Cold Spring Harbor Symp. Quant. Biol. 74:35-40 (2009)

•  Pandi L, Kollman JM, Lopez-Lira F, Burrows JM, Riley M, Doolittle RF.
Two families of synthetic peptides that enhance fibrin turbidity and delay fibrinolysis by different mechanisms.
Biochemistry 48:7201-7208 (2009)

•  Doolittle RF, Hong S, Wilcox D.
Evolution of the fibrinogen gamma' chain: implications for the binding of factor XIII, thrombin and platelets.
J Thromb. Haem. 7:1431-1433 (2009)

•  Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle RF.
Crystal structure of human fibrinogen.
Biochemistry 48:3877-3886 (2009)

•  Ponczek MB, Gailani D, Doolittle RF.
Evolution of the contact phase of vertebrate blood coagulation.
J Thromb. Haem. 6:1-8 (2008)

•  Doolittle RF.
Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolylsis.
Cardiovasc. & Hematol. Agents in Med. Chem. 6:181-189 (2008)

•  Doolittle RF, Jiang Y, Nand J.
Genomic evidence for a simpler clotting scheme in jawless vertebrates.
J Mol Evol. 66:185-196 (2008)

•  Doolittle RF, Pandi L.
Probing the b-Chain hole of Fibrinogen with Synthetic Peptides that differ at their amino termini.
Biochemistry. 46:10033-10038 (2007)

•  Doolittle RF, Chen A, Pandi L.
Differences in binding specificity for the homologous g-and b-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the b-chain hole.
Biochemistry. 45:13962-13969 (2006)

•  Doolittle RF, Chen A, Pandi L.
Supplementary Material
Differences in binding specificity for the homologous g-and b-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the b-chain hole.

•  Doolittle, RF, Kollman, JM.
Natively unfolded regions of vertebrate fibrinogen molecule.
Proteins. 63:391-7 (2006)

•  Doolittle RF, Pandi, L.
Binding of synthetic B knobs to fibrinogen changes the character of fibrin and inhibits its ability to activate tPA and its destruction by plasmin.
Biochemistry. 45:2657-67 (2006)

•  Kollman JM, Doolittle RF.
Unusual non-crystallographic symmetry in crystals
of a 420 kDa crustacean clottable protein.
Acta Crystallogr D Biol Crystallogr. 61:485-489 (2005)

•  Doolittle RF.
Evolutionary aspects of whole-genome biology.
Curr Biol Struct Biol 15:248-253 (2005)

•  Sirinupong N, Suwanmanee P, Doolittle RF, Suvachitanont W.
Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl CoA synthase gene from Hevea brasiliensis.
Planta. 221:502-512 (2005)

•  Doolittle RF.
Comments on John Ferry's most enduring paper.
Biophysical Chemistry 112:177-180 (2004)

•  Yang S, Doolittle RF, Bourne PE.
Phylogeny determined by protein domain content.
Proc Natl Acad Sci U S A. 102:373-378 (2005)

•  Doolittle RF.
Determining the crystal structure of fibrinogen.
J Thromb Haemost. 2:683-689 (2004)

•  Jiang Y, Doolittle RF.
The evolution of vertebrate blood coagulation as viewed
from a comparison of puffer fish and sea squirt genomes.
Proc Natl Acad Sci USA. 100:7527-7532 (2003)

•  Doolittle RF.
Structural basis of the fibrinogen-fibrin transformation:
contributions from X-ray crystallography.
Blood Rev. 17:33-41 (2003)

•  Doolittle RF.
Notes on Crystallizing Fibrinogen and Fibrin Fragments.
Biophysical Chemistry 100:307-313 (2003)

•  Spraggon G, Applegate D, Everse SJ, Zhang J, Veerapandian L, Redman C, Doolittle RF, Grieninger G.
Crystal structure of a recombinant alphaC domain from human fibrinogen-420.
Proc Natl Acad Sci USA. 95:9099-9104 (1998)

•  Doolittle RF
The evolution of vertebrate blood coagulation: a case of yin and yang.
Thrombosis Haemostasis 70:24-28 (1993)

•  Doolittle RF
A delicate balance.
Boston Review (February issue, 1997)

•  Kyte J, Doolittle RF.
A Simple Method for Displaying the Hydropathic Character of a Protein.
J Mol Biol. 157:105-132 (1982)

•  Doolittle RF.
Similar Amino Acid Sequences: Chance or Common Ancestry?
Science. (1981)

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Last Modified Sun. May 25, 2011